In Drosophila pupae, the detachment and expulsion of apoptotic cells from the epithelium is driven by: remodeling of adherens junctions between the apoptotic and neighboring cell surfaces, the contraction of actomyosin structures in both apoptotic and neighboring cells, and the modulation of […]
Non-junctional E-cadherin clusters play a non-canonical role in stabilizing the cortex and resisting its flow, in addition to their well-characterized role in mediating cell-cell junctions.
This study was published in Current Biology in 2017.
Padmanabhan A et al. Non-junctional E-cadherin clusters regulate the actomyosin cortex in the C. […]
This study addresses the role of formins at epithelial junctions. A major formin, mDia1, is shown to be recruited to Adherens Junctions (AJs) by E-Cadherin and RhoA. This leads to the organization of actomyosin filaments around the AJs which causes an increase in junctional contractility. […]
