How does talin buffer forces in cells?

Talin, a well-known mechanosensor, is able to buffer forces through the stochastic folding and unfolding of its various rod domains. By buffering cellular forces, talin defines the physiological force range in which a number of mechanosensitive cellular processes can take place.

These findings were published in Nature Communications […]

How does traction force affect the nature of adhesion structures like podosomes?

Yu et al showed that podosomes, which are usually formed by either macrophages or transformed cells, can also be formed by normal fibroblasts on fluid matrix devoid of any traction force. This was mediated by the phosphoinositide 3-kinase (PI3K) and PIP3 in […]