It has been shown that mouse fibroblasts efficiently dedifferentiate and express markers of pluripotency after being geometrically confined over 10 days, without exogenous biochemical factors. After 6 days mesenchymal genes are repressed, and after 10 days ESC and iPSC specific genes […]
The binding of H-NS to the bacterial DNA is initiated by electrostatic interactions between the positive residues on the H-NS linker and the negatively charged DNA. The initial contacts established by the linker then promotes engagement by the C-terminal DNA-binding domain of H-NS proteins.
These findings were published […]
This research provides the first direct visualization of functional gene clusters, at a nano-scale level. Functional gene clusters are genes that may be on the same or different chromosomes but are regulated by the same transcriptional factors that enable their intermingling with […]
