Proteins containing I-BAR (inverted Bin/amphiphysin/Rvs i.e. IRSp53 Missing-in-metastasis homology Domain or IMD) cooperate with various components of actin filament assembly, to promote filopodia protrusion, via several mechanisms including the stimulation of F-actin crosslinking 14645856 … Read more…
α-actinin primarily influences the cohesiveness and mechanics of the cytoskeleton by cross-linking actin filaments and other cytoskeleton components to create a scaffold that imparts stability and forms a bridge between the cytoskeleton and signaling pathways… Read more…
α-actinin is an actin-binding protein 5857097 and component of the actin crosslinking functional modules; it lacks G-actin binding activity and lacks actin initiation/nucleation activity 4076192 . α-actinin is an important organizer of the cytoskeleton that belongs to the spectrin superfamily (which includes spectrin, dystrophin, and related homologues)… Read More…
Fimbrin (aka plastin homologue, accumentin) is an actin binding protein that was originally identified in microvilli. Fimbrin represents one of the most basic structures of an actin crosslinking protein;… Read more…
Filamin forms a vital scaffolding adaptor and regulatory component that contributes to the mechanical stability of cells by linking the internal actin network with membrane receptors and mechanosensitive components. This function correlates with its distribution in cultured cells along actin stress fibers, within cortical actin networks and sometimes at membrane ruffles… Read more… […]
Filamin is an actin-binding protein that was first recognized (and named) for its filamentous colocalization with actin stress fibers. Filamin molecules are naturally found in cells as elongated, V-shaped dimers (i.e. two linked filamin molecules) that contain several immunoglobulin-like domains for protein interactions, amino-terminal actin-binding domains (ABD) composed of two calponin homology (CH) domains, […]
A steady pool of F-actin monomers or loosely linked F-actin promotes efficient polymerization and bundling of actin-filaments by fascin. Fascin is found in the most distal regions of filopodia and lamellipodia and the cellular distribution of fascin within actin bundles (e.g. microspikes and stress fibers 3525578 ) appears to vary depending upon the extracellular […]
Fascin is the major actin crosslinking protein found in a wide range of filopodia. This protein has been shown to work in concert with other cross linkers such as α-actinin to produce filopodia, although fascin itself is sufficient to form filopodia-like bundles in a reconstitution system…Read more…
Crosslinking of actin filaments is facilitated by actin binding proteins such as a-actinin, fascin or filamin. These proteins tether actin filaments together to strengthen the cytoskeleton, and enable their arrangement into higher order actin-based structures… Read More
