α-actinin primarily influences the cohesiveness and mechanics of the cytoskeleton by cross-linking actin filaments and other cytoskeleton components to create a scaffold that imparts stability and forms a bridge between the cytoskeleton and signaling pathways… Read more…

α-actinin is an actin-binding protein 5857097 and component of the actin crosslinking functional modules; it lacks G-actin binding activity and lacks actin initiation/nucleation activity 4076192 . α-actinin is an important organizer of the cytoskeleton that belongs to the spectrin superfamily (which includes spectrin, dystrophin, and related homologues)… Read More…