Summary
| Title | ‘Fork initiation and zipper’ model for adherens junction formation |
| Description | Initial cell-cell contacts are mediated by nectin-nectin trans interactions that activate the Rho GTPase Cdc42. Cdc42 stimulates an increase in filopodial protrusions during a phase termed ‘fork initiation’. This promotes more trans interactions between nectins as well as cadherins. Further downstream signaling via Cdc42 activates Rac GTPase and leads to the ‘zipper’ phase, whereby lamellipodial protrusions seal the gaps between filopodial cell-cell contacts. |
| Date | 2012 |
| Referred pages | Adherens Junction Assembly |
| License | Creative Commons Attribution-NonCommercial 4.0 International License |
| Permission | Modification, copying and distribution (commercial) of this image is strictly prohibited without written consent. Please contact MBInfo at [email protected] to request permission to use this image. |
How to cite this page?
‘Fork initiation and zipper’ model for adherens junction formation. In MBInfo Wiki, Retrieved 10/21/2014 from http://mbinfo.mbi.nus.edu.sg/figure/1384242572605/
