Title | ‘Fork initiation and zipper’ model for adherens junction formation |
Description | Initial cell-cell contacts are mediated by nectin-nectin trans interactions that activate the Rho GTPase Cdc42. Cdc42 stimulates an increase in filopodial protrusions during a phase termed ‘fork initiation’. This promotes more trans interactions between nectins as well as cadherins. Further downstream signaling via Cdc42 activates Rac GTPase and leads to the ‘zipper’ phase, whereby lamellipodial protrusions seal the gaps between filopodial cell-cell contacts. |
Date | 2012 |
Referred pages | Adherens Junction Assembly |
License | Creative Commons Attribution-NonCommercial 4.0 International License |
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