Summary
| Title | Dynamic instability of microtubules |
| Description | (A) The intracellular concentration of tubulin found in most cells (10-20µM) favors microtubule assembly at the plus end. This end may appear frayed in slow growing filaments due to fewer lateral interactions between the protofilaments and because GDP-tubulin dimers have an inherent curve. (B) At high free GTP-tubulin dimer concentrations, hydrolysis is outpaced by rapid assembly at the plus end, thereby forming a rigid GTP-cap. (C) Concerted GTP hydrolysis at the plus end weakens the tubulin dimer interactions and the protofilaments rapidly disassemble. |
| Date | 2012 |
| Referred pages | Dynamic Instability of Microtubules |
| License | Creative Commons Attribution-NonCommercial 4.0 International License |
| Permission | Modification, copying and distribution (commercial) of this image is strictly prohibited without written consent. Please contact MBInfo at [email protected] to request permission to use this image. |
How to cite this page?
Dynamic instability of microtubules. In MBInfo Wiki, Retrieved 10/21/2014 from http://mbinfo.mbi.nus.edu.sg/figure/1384243769869/
