Title | Dynamic instability of microtubules |
Description | (A) The intracellular concentration of tubulin found in most cells (10-20µM) favors microtubule assembly at the plus end. This end may appear frayed in slow growing filaments due to fewer lateral interactions between the protofilaments and because GDP-tubulin dimers have an inherent curve. (B) At high free GTP-tubulin dimer concentrations, hydrolysis is outpaced by rapid assembly at the plus end, thereby forming a rigid GTP-cap. (C) Concerted GTP hydrolysis at the plus end weakens the tubulin dimer interactions and the protofilaments rapidly disassemble. |
Date | 2012 |
Referred pages | Dynamic Instability of Microtubules |
License | Creative Commons Attribution-NonCommercial 4.0 International License |
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