Summary
| Title | Formin-mediated nucleation of actin filaments |
| Description | The FH2 domains of the formin dimer (shown in green) bind to actin monomers to initiate filament assembly. Recent studies indicate this is assisted, or even mediated, by additional factors such as APC. The FH1 domains of the formin dimer (shown as black lines) have short polyproline sequences that interact with profilin. Profilin binds to both formin and actin monomers to increase the addition of actin monomers to the barbed end of the filament. |
| Date | 2011 |
| Referred pages | Actin NucleatorsActin Filament Elongators |
| License | Creative Commons Attribution-NonCommercial 4.0 International License |
| Permission | Modification, copying and distribution (commercial) of this image is strictly prohibited without written consent. Please contact MBInfo at [email protected] to request permission to use this image. |
How to cite this page?
Formin-mediated nucleation of actin filaments. In MBInfo Wiki, Retrieved 10/21/2014 from http://mbinfo.mbi.nus.edu.sg/figure/1384245084401/
