MBInfo - Cellular Functions in Mechanobiology

Mechanobiology

Mechanobiology is a discipline that aims to understand how mechanical force and cellular geometry interplay with biochemical activities to drive cellular functions. With individual cellular activities culminating to shape whole organisms, form is linked to function, and dynamic feedback mechanisms arise between mechanics and biochemistry.

What is mechanobiology? | Physiological relevance

What is MBInfo

MBInfo is a unique, multipurpose information resource, created at the Mechanobiology Institute, Singapore. MBInfo provides in-depth reviews on the mechanics of cellular and molecular function. Using the wiki functions, you can help keep the site up to date, with the latest findings and hypotheses.

Simply click the ‘edit’ link on any page or section, and login using your Google account.

How do I edit? | Contributors

Topics in Mechanobiology

Cellular process often occur within distinct cellular regions or compartments. However, they do not occur independently as one process may regulate another, or provide the components or resources for mechanisms carried out in distant regions of the cell… Read more	Within nearly every cell exists a protein-based framework that provides structural support, provides tracks for the transport cargo, facilitates the generation of force and can be exploited for the transduction of mechanical signals. This network is highly dynamic, … Read more	Cells constantly communicate with each other. A molecular handshake between neighbouring cells, or the pull of a cell matrix adhesion, will initiate the transfer of information through a multitude of signaling pathways. Whether chemical, mechanical or electrical; long-distance or local, … Read more	Molecular factories exist throughout every cell, persistently and efficiently synthesizing molecular components, proteins and lipids to keep up with the demands of cellular life. From the genetic blueprint contained within DNA, through to a perfectly folded and … Read more
Cellular Organization	Cytoskeleton Dynamics	Mechanosignaling	Synthesis

Cutting Edge Methods and Technology

With countless intracellular feedback mechanisms regulating each various function of the cell, developing methods to study these functions often requires new technologies and unique procedures. This topic will explore several of the methods commonly used in the field of mechanobiology.

Resources

Recent Updates

Contractile Fiber Updated on: Fri, 15 Nov 2013 01:01:26 GMT

Microfilament or microtubule assembly or disassembly against a force. Proc. Natl. Acad. Sci. U.S.A. 1981; 78(9). [PMID: 6946498]
Lamellipodium Assembly Updated on: Fri, 15 Nov 2013 01:01:26 GMT

Peskin CS., Odell GM., Oster GF. Cellular motions and thermal fluctuations: the Brownian ratchet. Biophys. J. 1993; 65(1). [PMID: 8369439]
Lamellipodium Assembly Updated on: Fri, 15 Nov 2013 01:01:26 GMT

Loisel TP., Boujemaa R., Pantaloni D., Carlier MF. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature 1999; 401(6753). [PMID: 10524632]
Lamellipodium Assembly Updated on: Fri, 15 Nov 2013 01:01:26 GMT

Borisy GG., Svitkina TM. Actin machinery: pushing the envelope. Curr. Opin. Cell Biol. 2000; 12(1). [PMID: 10679366]
Podosome Assembly Updated on: Fri, 15 Nov 2013 01:01:26 GMT

The polymerization motor. Traffic 2000; 1(1). [PMID: 11208055]

Mechanobiology

What is MBInfo

Topics in Mechanobiology

Cellular Organization

Cytoskeleton Dynamics

Mechanosignaling

Synthesis

Cutting Edge Methods and Technology

Resources

Recent Updates