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Arp2/3 complex

Glossary Term: Arp2/3 Complex


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Arp2/3 is a protein complex of seven subunits that is involved in the nucleation and assembly of branched actin filaments. The Arp2/3 complex is highly conserved and is found in most eukaryotes. Branched nucleation by the Arp2/3 complex requires a pre-formed actin filament and is regulated by proteins such as WASp and Cdc42.

Figure: Reconstruction of Arp2/3 complex-mediated nucleation. Arp2/3 complex initiates a new branched filament by binding to the side of the mother filament and recruiting actin monomers. Components of the Arp2/3 complex remain at the pointed end of the filament. (Figure adapted from [1]).


References

  1. Rouiller I., Xu XP., Amann KJ., Egile C., Nickell S., Nicastro D., Li R., Pollard TD., Volkmann N. & Hanein D. The structural basis of actin filament branching by the Arp2/3 complex. J. Cell Biol. 2008; 180(5):887-95. [PMID: 18316411]
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Steven Wolf,
Mar 5, 2013, 7:52 PM