Introduction to Cytoskeleton-dependent Intracellular Transport[Edit]
Along with providing structural support to the cell, and transmitting force signals, cytoskeletal filaments also provide cells with a network of ‘tracks’ that can be followed by specific proteins for the directed delivery of vesicles and their subcellular ‘cargo’. This process is essential in ensuring an adequate concentration of required components is maintained at sites undergoing rapid or modulation, or where a specific subcellular process is being carried out. For example, filopodial extension during cell migration requires numerous components, and occurs rapidly, yet has limited access to the cytoplasm and any soluble components.
Cargo that can be delivered or by cytoskeleton-dependent intracellular transport mechanisms can include other proteins and complex components. This delivery process is analogous to a freight train carrying cargo to specific locations, as dictated by the presence of railway tracks. Similar to a freight train, motor proteins capable of carrying cargo also face restrictions in the direction they can travel, the speed at which they travel and the possibility of traffic jams along the route.
Cargo that can be delivered or by cytoskeleton-dependent intracellular transport mechanisms can include other proteins and complex components. This delivery process is analogous to a freight train carrying cargo to specific locations, as dictated by the presence of railway tracks. Similar to a freight train, motor proteins capable of carrying cargo also face restrictions in the direction they can travel, the speed at which they travel and the possibility of traffic jams along the route.