The following classes of proteins/ events are known to enhance or inhibit integrin activation in various contexts. It must be noted that this list provides just a few examples of proteins that regulate the activation of integrin.

1. Regulators of talin recruitment

Proteins with membrane targeting motif that bind to talin [reviewed in Shattil 2010]
i. Rap1-RIAM (Talin activation) [Lafuente et al 2004, Bos 2005, Han et al 2006]
ii. WAVE [Nolz 2007]
iii. Fam38A/r-Ras (Talin activation by calpain cleavage) [McHugh 2010]

2. Phosphorylation of integrin cytoplasmic domains

i. Tyr Phosphorylation -promote reduce talin affinity, promote Dok1 binding or other PTB domain proteins [ Calderwood 2003, Anthis JBC 2009, Oxley 2008]
ii. PKA mediated Ser phosphorylation- α4β1 recruitment and activation at the leading edge [Han 2003, Lim 2008]
iii. Src-kinase mediated Tyr phosphorylation of beta integrin ([Anthis JBC 2009],reviewed in [Gahmberg et al 2009])- may not have downstream effect always [Meves 2011]

3. Competitors for talin

i. Filamin and Migfilin [Kiema 2006, Lad 2008, Ithychanda 2009]
ii. CIB1 and its paralogues binding to α cytoplasmic tail [Yuan 2006, Denofrio 2008]
iii. PIPKIγ90 [Martel et al 2001, Ling et al 2003, Calderwood et al 2004]

4. ERK1 and ERK2

5. Trans-dominant inhibition of activation [Calderwood JBC 2009]