Steps in Formation
1. Initiation and Nucleation
2. Extension, Pause and Stasis 3. Formation of Adhesions 4. Force Generation and Translocation 5. Disassembly of actin filaments and adhesions Functional Modules
| Lamellipodia and Lamella
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References
- Lai FP., Szczodrak M., Block J., Faix J., Breitsprecher D., Mannherz HG., Stradal TE., Dunn GA., Small JV. & Rottner K. Arp2/3 complex interactions and actin network turnover in lamellipodia. EMBO J. 2008; 27(7):982-92. [PMID: 18309290]
- Peskin CS., Odell GM. & Oster GF. Cellular motions and thermal fluctuations: the Brownian ratchet. Biophys. J. 1993; 65(1):316-24. [PMID: 8369439]
- Insall RH. & Machesky LM. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev. Cell 2009; 17(3):310-22. [PMID: 19758556]
- Forscher P., Lin CH. & Thompson C. Novel form of growth cone motility involving site-directed actin filament assembly. Nature 1992; 357(6378):515-8. [PMID: 1608453]
- Theriot JA. & Mitchison TJ. Actin microfilament dynamics in locomoting cells. Nature 1991; 352(6331):126-31. [PMID: 2067574]
- Koestler SA., Auinger S., Vinzenz M., Rottner K. & Small JV. Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front. Nat. Cell Biol. 2008; 10(3):306-13. [PMID: 18278037]
- Choi CK., Vicente-Manzanares M., Zareno J., Whitmore LA., Mogilner A. & Horwitz AR. Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat. Cell Biol. 2008; 10(9):1039-50. [PMID: 19160484]